Fig. 1.

Experimental Design Used to Study Early Preventive Antipsychotic and Antidepressant Drug Treatment in the Present Infection-Based Neurodevelopmental Mouse Model of Schizophrenia-Like Disorder. Pregnant mice on GD 9 were exposed to PolyI:C (2 mg/kg, intravenously) or corresponding control (CON, saline) treatment. The resulting offspring from both treatment conditions (ie, PolyI:C offspring and CON offspring) were then subjected to chronic antipsychotic (haloperidol or clozapine), antidepressant (fluoxetine), or vehicle treatment during the periadolescent stage of development, ie, between postnatal days (PNDs) 35 and 65. On PND 65, the periadolescent drug regime was stopped. Behavioral and pharmacological testing of the offspring was conducted in adulthood (ie, between PNDs 90 and 120) in a drug-free state.