Table 1.

Summary of the Number of Subjects Used in the Behavioral and Pharmacological Assays at Adult Age

	CON Offspring				PolyI:C Offspring
	VEH	HAL	CLZ	FLX	VEH	HAL	CLZ	FLX
PPI	21 ♂, 22 ♀	10 ♂, 11 ♀	9 ♂, 9 ♀	13 ♂, 11 ♀	14 ♂, 16 ♀	8 ♂, 8 ♀	9 ♂, 10 ♀	9 ♂, 9 ♀
LI
NPE	13 ♂, 14 ♀	6 ♂, 8 ♀	6 ♂, 5 ♀	6 ♂, 6 ♀	11 ♂, 11 ♀	4 ♂, 4 ♀	5 ♂, 5 ♀	4 ♂, 5 ♀
PE	11 ♂, 12 ♀	6 ♂, 8 ♀	5 ♂, 5 ♀	6 ♂, 5 ♀	10 ♂, 9 ♀	4 ♂, 4 ♀	5 ♂, 4 ♀	5 ♂, 5 ♀
AMPH sensitivity	8 ♂, 7 ♀	6 ♂, 5 ♀	4 ♂, 4 ♀	5 ♂, 5 ♀	9 ♂, 8 ♀	5 ♂, 4 ♀	5 ♂, 4 ♀	5 ♂, 5 ♀
MK-801 sensitivity	10 ♂, 9 ♀	4 ♂, 5 ♀	5 ♂, 5 ♀	5 ♂, 6 ♀	9 ♂, 9 ♀	3 ♂, 4 ♀	4 ♂, 5 ♀	4 ♂, 4 ♀

Note: CON, control; PolyI:C, polyriboinosinic-polyribocytidylic acid; VEH, vehicle; HAL, haloperidol; CLZ, clozapine; FLX, fluoxetine; PPI, prepulse inhibition; LI, latent inhibition; NPE, non-preexposure; PE, preexposure; AMPH, amphetamine; PND, postnatal day. Male and female offspring born to PolyI:C-exposed or CON mothers were treated with VEH, HAL, CLZ, or FLX during periadolescence, ie, between PNDs 35 and 65. They were then subjected to repeated behavioral and pharmacological phenotyping at adult age (PNDs 90–120) in drug-free state. Phenotyping of the offspring started with the paradigm of PPI, followed by LI and sensitivity to the psychostimulant drugs AMPH and dizocilpine (MK-801). All subjects were behaviorally naive at the beginning of testing (PPI). In order to increase the number of subjects necessary for the LI test, behaviorally naive animals were also included in this test in addition to the ones tested previously in the PPI paradigm. The AMPH and MK-801 sensitivity tests were conducted in 2 separate cohorts of drug-naive animals to avoid repeated psychostimulant drug exposure.