Table 3.

Effects of Periadolescent Antipsychotic or Antidepressant Drug Exposure on Locomotor Activity as Indexed by the Spontaneous Shuttles Performed During the Latent Inhibition Test

	Periadolescent Drug Treatment
	VEH	HAL	CLZ	FLX
PE day (total spontaneous shuttles)	131 ± 6	212 ± 11*	132 ± 10	1431 ± 8
Conditioning day (total ITI shuttles)	13 ± 1	27 ± 4*	11 ± 2	14 ± 1

Note: VEH, vehicle; HAL, haloperidol; CLZ, clozapine; FLX, fluoxetine; PE, preexposure; ITI, intertribal interval; in the PE phase of the test, the total number of spontaneous shuttles between the 2 compartments of the shuttle box was taken to index locomotor activity; on the day of conditioning, the mean number of ITI shuttles per 10-trial block served as an index for locomotor activity. Periadolescent exposure to HAL significantly increased the number of spontaneous shuttles during the PE phase in comparison to periadolescent VEH, CLZ, or FLX treatment. This effect of the HAL regime emerged regardless of the prenatal treatment histories, stimulus PE conditions, and sex. Periadolescent HAL administration also increased spontaneous locomotor activity as indexed by the spontaneous ITI shuttles performed during conditioning. *P < .001 between animals treated with HAL compared with all other periadolescent drug conditions, based on Fisher post hoc comparisons. All values are means ± standard error of the mean.