Table 4.

Summary of the Identified Beneficial and Detrimental Effects of Preventive Pharmacotherapy During Periadolescence on Adult Behavioral and Pharmacological Functions in Prenatally Immune-Challenged Mice (PolyI:C Offspring) and CON Mice (CON Offspring)

	CON Offspring			PolyI:C Offspring
	HAL	CLZ	FLX	HAL	CLZ	FLX
Prepulse inhibition	−	0	0	0	+	+
Latent inhibition	0	0	−	+	+	0
AMPH sensitivity	−	0	0	+	0	+
MK-801 sensitivity	−	0	−	+	0	0

Note: PolyI:C, polyriboinosinic-polyribocytidylic acid; CON, control; HAL, haloperidol; CLZ, clozapine, FLX, fluoxetine; AMPH, amphetamine. Symbols (−), (+), and (0) denote detrimental, beneficial, and no significant effects of the periadolescent drug treatment, respectively, with respect to corresponding placebo treatment in CON and PolyI:C offspring.