Fig. 2.
Proof of Concept That Alterations in Radioligand Binding Can Reflect Endogenous Neurotransmitter Concentrations. A direct negative correlation can be observed between radioligand binding to dopamine D2 receptors (measured with the neuroleptic radioligand tracer IBZM) and endogenous dopamine concentrations (measured with microdialysis) following prefrontal stimulation with amphetamine to mimic stress effects in nonhuman primates (7).