Table 1.

Conditions predisposing to atypical hemolytic uremic syndrome

Complement regulatory defects

Factor H mutations

Factor I mutations

MCP mutations

Factor H autoantibodies

Factor B mutations

Bacterial

Streptococcus Pneumoniae

Viruses

HIV

Drugs

Chemotherapy (mitomycin C, gemcitabine, cisplatin, bleomycin)

Quinine

Calcineurin inhibitors (cyclosporine, tacrolimus)

Bevacizumab

Oral contraceptives

Illicit drugs (cocaine, heroin, ecstasy)

Systemic disease

Systemic lupus erythematosus

Scleroderma

Anti-phospholipid antibody

Pregnancy

Cancer

Hepatocellular carcinoma

Prostate adenocarcinoma

Gastric adenocarcinoma

Combined methylmalonic aciduria and homocystinuria

Adapted from Kavanagh, et al. Br Med Bull 2006;77–78:5–22. Reprinted with permission from Oxford University Press.