Table 1.

S100 proteins and RAGE: binding equilibrium

		Total bovine RAGE			Glycan Enriched bovine RAGE
Purified human ligands	Bmax (mole/mole)	Kd (nM)	Bmax/Kd (×10−4)	Bmax (mole/mole)	Kd (nM)	Bmax/Kd (×10−4)
			Av.Binding potential			Av.Binding potential
S100A8/A9*	0.0114±0.002	34.4±13	4	0.402±0.03	7.62±1.83	560
				>30 fold ↑		>100 fold ↑
S100A12	1.2±0.2	51.8±20.6	300	44.5±8.5	133±46.4	3600
				>30 fold ↑		>10 fold ↑
S100A11	0.04±0.003	53.1±7.8	0.7	0.03±0.002	30.9±3.6	1.1

^*The parameters for S100A8/A9 were published earlier [Turovskaya et al., 2008]