Figure 2.

Overview of CSC intracellular trafficking. Shown in purple are hexameric CSC rosettes that are targeted to the plasma membrane (PM) directly from the Golgi (G) or from SmaCC/MASCs (SM). Recycling occurs from the plasma membrane to SmaCC/MASCs (double arrow), and CSC insertion appears to occur only in the vicinity of microtubules (MT). There is a delay following CSC insertion in the plasma membrane and the start of microfibril (MF) biosynthesis. SmaCC/MASCs track along both ends of depolymerizing microtubules.