Fig. 16.

Strategies for drug discovery with a dimeric or dimerizing receptor tyrosine kinase. a, schematic illustration of the mechanism of receptor tyrosine kinase activation by ligand-induced dimerization. b, schematic illustration of the various possible strategies for the search/design of ligand mimetics and antagonists. PTP, protein tyrosine phosphatase; TK, tyrosine-kinase domain. [Reproduced from De Meyts P and Whittaker J (2002) Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 1:769–783. Copyright © 2002 Nature Publishing Group. Used with permission.]