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Schematic of the IGF-IR dimer demonstrating the distribution of domains across α and β chains and the location of α-β disulfides and α-α dimer disulfide bonds. [Adapted from Clemmons DR (2001) IGF-I receptor-mediated signal transduction, in Targets for Growth Hormone and IGF-I Action (Bouillon R ed), pp 17–28, Bioscientifica Ltd., Bristol, UK. Copyright © 2001 Bioscientifica Ltd. Used with permission.]
