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A, uptake of DDP after 1 h pretreatment with either 200 μM CuSO4, 100 μM BCS, or drug-free media. Data shown are whole-cell nanograms of platinum accumulation per microgram of sulfur. B, DDP concentration-survival curves for 2008 cells with (◊) and without (■) pretreatment with 200 μM CuSO4 for 1 h. C, DDP concentration-survival curves for 2008 cells with (◊) and without (■) pretreatment with 100 μM BCS for 1 h.
