TABLE 4.
Summary of screening results on NR2D-containing NMDA receptors
Numbers in parenthesis are percentage of the number of compounds in the individual libraries or the total number of compounds screened. Only hits from the primary screening assay that was commercially available as powder were tested in the secondary screen (TEVC recordings).
Library | Compounds Screened | Hits from Screening Assay | Hits Tested in TEVC Recordings | Hits Verified in TEVC Recordings |
---|---|---|---|---|
NRA | 520 | 70 (13.5) | 62 (11.9) | 24 (4.6) |
LOPAC | 1280 | 44 (3.4) | 41 (3.2) | 27 (2.1) |
Total | 1800 | 114 (6.3) | 103 (5.7) | 51 (2.8) |