Fig. 4.
Ethanol increases the number of open 5-HT3A(QDA) channel events and increases the open probability. Left, cell-attached recordings of 5-HT3A(QDA) receptor-mediated currents evoked by 100 μM 5-HT in the absence (A) or presence (B) of 25 mM ethanol. Twenty-second examples of single-channel activity with an expanded view of a burst. Dotted lines indicating closed and open states. Right, all-points histograms for the 20-s cell-attached recordings of 5-HT3A(QDA) receptor-mediated currents evoked by 100 μM 5-HT shown in the left panel. Histograms were fitted by two Gaussians (gray lines). Percentages of events in the closed and open states are shown.