TABLE 1.

Ethanol evokes a fourth open state

Open times (milliseconds) and their corresponding proportions (in parentheses, percentage) for 5-HT_3A(QDA) receptor-mediated currents evoked by 100 μ M 5-HT in the absence and presence of 25 mM ethanol. For each condition, data were collected and pooled from four cell-attached patches at a predicted membrane potential of −80 mV.

	τ1	τ2	τ3	τ4
100 μM 5-HT	0.3 ± 0.05 (63 ± 2)	2.8 ± 0.13 (20 ± 2)	24.3 ± 0.11 (17 ± 1)
100 μM 5-HT + 25 mM ethanol	0.4 ± 0.1 (42 ± 2)	2.9 ± 0.1 (29 ± 2)	20 ± 0.2 (13 ± 1)	273 ± 0.1 (16 ± 1)