Fig. 10.

Representative fluorescent photomicrographs (of four experiments) of phalloidin staining of the kidney tissues (magnification: 400×) from sham-operated A₁WT mice (A₁WT sham; A) and A₁KO mice (A₁KO sham; B), A₁WT mice (A₁WT hepatic IR; C) or A₁KO mice (A₁KO hepatic IR; D) subjected to 60 min of hepatic ischemia and 24 h of reperfusion, and A₁WT mice pretreated with 0.4 mg/kg DPCPX (A₁WT hepatic IR+DPCPX; E) or 0.1 mg/kg CCPA (A₁WT hepatic IR+CCPA; F) and subjected to 60 min of hepatic ischemia and 24 h of reperfusion. In the kidney, F-actin stains of proximal tubular epithelial cells are prominent in the brush border from sham-operated mice (*), which is severely degraded in the kidneys of mice subjected to liver IR (#).