Fig. 2.

Comparison of mean plasma creatinine (A; mg/dl) and ALT activity (B; U/liter) measured from sham-operated A₁WT mice (n = 4) and A₁KO mice (n = 4), sham-operated A₁KO mice renally injected with EGFP-encoding lentivirus (100 μl, n = 5), A₁WT mice (n = 6) or A₁KO mice (n = 6) subjected to hepatic IR, and A₁KO mice renally injected with EGFP (n = 5) or EGFP-huA₁AR mice encoding lentivirus (20 or 100 μl, n = 5 each) and subjected to hepatic IR. Mice were renally injected with lentivirus 48 h before sham surgery or hepatic IR. Plasma ALT and creatinine was measured at 24 h after reperfusion. *, P < 0.05 versus sham-operated mice. #, P < 0.05 versus A₁WT mice subjected to liver IR. +, P < 0.05 versus A₁KO mice injected with EGFP lentivirus. Error bars represent 1 S.E.M.