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. 2010 Jun;333(3):854–864. doi: 10.1124/jpet.109.165084

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Fig. 2. — Plasma and brain pharmacokinetic profiles of D3R analogs in male Sprague-Dawley rats (n = 3/time point). A, observed (mean ± S.D.) and predicted plasma concentration versus time profiles of the fluorenyl amides based on the naive averaging analysis conducted with WinNonlin. B, observed brain concentrations (mean ± S.D.) versus time profiles of the fluorenyl amides. C, observed (mean ± S.D.) and predicted plasma concentration versus time profiles of the 2-pyridylphenyl amides. D, observed brain concentrations (mean ± S.D.) versus time profiles of the 2-pyridylphenyl amides.