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. 2010 Jun;333(3):854–864. doi: 10.1124/jpet.109.165084

Fig. 5.

Fig. 5.

Stimulation of human P-gp (A), rat P-gp (B), human BCRP (C), rat BCRP (D), human MRP2 (E), and rat MRP2 (F) ATPase activity by increasing concentrations of NGB 2904 and PG 01037. Stimulation of ATPase activity was estimated by measuring inorganic phosphate released from ATP in the presence or absence of their respective controls or D3R analogs (NGB 2904 and PG 01037; 5–100 μM). The drug-stimulated ATPase activity was reported as fold-stimulation relative to the basal ATPase activity in the absence of drug (DMSO control). Data are represented as mean fold stimulation of the average control from triplicate reactions mean ± S.D. *, p < 0.05.