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. 2010 Jun;333(3):854–864. doi: 10.1124/jpet.109.165084

TABLE 3.

Intrinsic clearance values for 5 μM NGB 2904 and PG 01037 in human and male Sprague-Dawley rat pooled liver microsomes (0.8 mg/ml)

Intrinsic clearance is reported as microliters per minute per milligram of protein (n = 3/reaction).

Microsomal Preparation Intrinsic Clearance (5 μM)
NGB 2904 PG 01037
Pooled human liver microsomes 29.95 ± 3.83 25.62 ± 1.52
Pooled male rat liver microsomes 55.85 ± 3.05a,b 26.20 ± 5.67
a

P < 0.05 based on Newman-Keuls test, intrinsic clearance of NGB 2904 in human liver microsomes compared with rat liver microsomes.

b

P < 0.05 based on Newman-Keuls test, intrinsic clearance of NGB 2904 in rat liver microsomes compared with intrinsic clearance of PG 01037 in human and rat liver microsomes.