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TK/TD relationships between GHB cerebrospinal fluid concentrations and RRR. GHB (400, 600, or 800 mg/kg) was administered by intravenous bolus. When animals regained their righting reflex, CSF was obtained from the cisterna magna. Data are presented as mean ± S.D. (n = 7–8/dose). *, P < 0.05 compared with 400 mg/kg dose.
