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Mean percentage changes in GABA and glutamate in discrete brain regions at RRR after administration of 400, 600, or 800 mg/kg i.v. GHB
Percentage changes were calculated based on mean RRR for a given dose group.
| Dose | GABA |
Glutamate |
||||
|---|---|---|---|---|---|---|
| Frontal Cortex | Striatum | Hippocampus | Frontal Cortex | Striatum | Hippocampus | |
| % baseline | ||||||
| 400 mg/kg | 92.9 | 97.8 | 93.4 | 78.4 | 79.9 | 93.9 |
| 600 mg/kg | 94.9 | 119.0 | 91.6 | 92.5 | 87.1 | 97.8 |
| 800 mg/kg | 102.5 | 98.3 | 91.8 | 99.7 | 66.7 | 81.8 |
