Table 1.

The computational methods used for analyzing the network model

	Computational methods	Searching principle	Reference
Sensitivity analysis	Local sensitivity	Local
	Average of local sensitivities	Global	[17]
	Sobol's method		[11]
	First-order sensitivity	Global
	Total-effect sensitivity	Global
Parameter estimation	Local estimation	Local, deterministic
	Multi-start of local estimations	Global, deterministic
	Evolutionary strategy using stochastic ranking (SRES)	Global, stochastic	[22]