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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Trends Endocrinol Metab. 2010 Mar 10;21(6):345–352. doi: 10.1016/j.tem.2010.01.009

Figure 3.

Figure 3

Comparison of (a) blood glucose levels, (b) wet sawdust, a reflection of polyuria, (c) water bottle volume, an index of polydipsia, and (d) glycosuria in obese db/db mice and age-matched db/db mice in which obesity was prevented by transgenic expression of the leptin receptor on an aP2 promoter (db/db-tg). Clearly the absence of obesity accelerates the appearance of T2DM by about 5 weeks. The transgene on adipocytes prevents adipocyte hypertrophy, which attenuates the usual obesity-associated hyperleptinemia. The limited adipogenesis in these mice was associated with marked increase in ectopic lipid deposition, again absolving obesity as a cause of metabolic syndrome.