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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer Res. 2010 May 18;70(11):4280–4286. doi: 10.1158/0008-5472.CAN-09-4645

Figure 1. Histological analysis of pancreata.

Figure 1

(A) H&E stained sections from pancreata at 20 weeks of PDX-1-Cre:Notch1lox/lox mice (i = islet), PDX-1-Cre:LSL-K-rasG12D mice (arrowhead = tubular complexes-TC), and PDX-1-Cre:LSL-K-rasG12D:Notch1lox/lox mice (arrows = ducts exhibiting PanIN 1B-2 changes). Scale bar = 400μm. (B-D) Detailed characterization of pathology exhibited in PDX-1-Cre:LSL-K-rasG12D:Notch1lox/lox pancreata. (B) PanIN1B; papillary ductal lesions without significant loss of polarity or nuclear atypia (arrows). (C) PanIN1B transiting to PanIN2 revealing moderate nuclear atypia and a loss of polarity. (D) PanIN1B showing intraepithelial polymorphonuclear leukocytes (arrowheads). Scale bar = 200μm.