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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Cytokine. 2010 Mar 27;51(1):1–9. doi: 10.1016/j.cyto.2010.02.018

Fig. 1.

Fig. 1

A. Amino acid sequence alignment of HIV1 Vpr and HIV2 Vpr/Vpx. HIV1 Vpr shares about 50% and 25% protein sequence identity with HIV2/SIVmac Vpr and Vpx, respectively [78, 81]. The region of HIV1 Vpr and HIV2 Vpr that overlaps with Tat is shaded in purple and the region of HIV1 Vpr and HIV2 Vpx that overlaps with Vif is shaded in grey. The amino acids that are predicted to form three alpha-helices are indicated. B. Proviral genome structure of HIV. Vpr is encoded by a reading frame in the center of the HIV1 genome that overlaps both vif and tat reading frames. HIV2 and the closely related virus SIVsmm/mac encode two vpr-like genes, vpx and vpr. C. The functions of Vpr. HIV1 Vpr is a multi-functional protein whose functions segregate to HIV2 Vpr or Vpx.