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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer Res. 2010 May 18;70(11):4666–4675. doi: 10.1158/0008-5472.CAN-09-3970

Figure 5. The rapamycin analogue RAD001 inhibits adrenocortical tumor cell growth in vitro and in vivo.

Figure 5

A, H295R (red squares), SW-13 (blue triangles), primary ACT (purple circles) and HAC15 (green triangles) cells were cultured in 24-well plates in the presence of DMSO (D) or of increasing concentrations of RAD001. Cells were counted after 6 days of culture in the presence of the drug. SEM is indicated. Data were generated from three different experiments each performed in duplicate. B, H295R xenograft growth in NOD/SCID/γcnull mice treated with placebo (black squares) or with RAD001 (10/mg/kg/day; red triangles). SEM is indicated. Tumor growth was significantly different (**p<0.01, paired t-test) in animals treated with the drug.