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(A–B), B16F1 cells were embedded in a 3-dimensional matrix of FibFN and analyzed for invadopodia formation after 16 hours. (A), invasion of FibFN-embedded B16F1 cells after treatment with ε-aminocaproic acid, aprotinin or the broad spectrum MMP inhibitor GM6001. (B), invasion of FibFN-embedded B16F1 cells after treatment with TIMP1, TIMP2 or MT1-MMP siRNA.
