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. Author manuscript; available in PMC: 2011 May 14.
Published in final edited form as: Circ Res. 2010 Mar 25;106(9):1541–1548. doi: 10.1161/CIRCRESAHA.109.212753

Figure 3.

Figure 3

PGC-1 pathway in human failing hearts. (A) Fold changes ± SEM in gene expressions for the PGC-1 pathway in the Failing (n=23) hearts relative to Non-Failing controls (n=9). (B) Protein levels of the transcription regulators for mitochondrial biogenesis. Representative Western blots for PGC-1α, ERRα, ERRγ, TFAM, TFB2M and GAPDH, and average fold changes (mean ± SEM) of the Failing (n=6) hearts relative to the Non-Failing controls (indicated by the dashed line; n=5; * p<0.05). (C) mRNA levels of the PGC-1α downstream gene targets mediated by ERRα or ERRα and PPARα encoded by nDNA (white bars) or mtDNA (black bars) in the Failing hearts (n=23). Data are shown as the mean of the fold changes ± SEM over the Non-Failing hearts (indicated by the dashed line; n=9; * p<0.05 vs. Non-Failing).