Table 3.
Prediction of environmental chemicals associated with lung cancer samples (GSE10072).
| Chemical Predicted | Hypergeometric P-value | Rank (percentile) | q-value | Relevant genes in set (number of references) | Citations |
|---|---|---|---|---|---|
| Doxorubicin | 1 × 10-6 | 16 (99) | 4 × 10-4 | CASP3(60), ABCB1(28), BAX(26), BCL2 (23) | [54] |
| Sodium arsenite | 8 × 10-6 | 20 (98) | 4 × 10-4 | JUN(13), NQ01(6), EGR1(6) | [55-57] |
| Vanadium pentoxide | 1 × 10-5 | 24 (98) | 6 × 10-4 | HBEGF(3), CDK7(1), CDKN1B (1), CDKN1C(1) | [58] |
| Dimethylnitrosamine | 6 × 10-5 | 27 (98) | 7 × 10-4 | TGFB1(23), TIMP1(15), PCNA(6) | [31] |
| Indomethacin | 2 × 10-4 | 34 (97) | 0.002 | BIRC5(3), CDKN1B(2), MMP9(2) | [59-61] |
| 2-Acetylaminofluorene | 3 × 10-4 | 36 (97) | 0.003 | ABCB1(4), ABCG2(4), KRT19(2) | [62] |
| Asbestos, Serpentine | 4 × 10-4 | 39 (97) | 0.004 | IL6(2), MMP9(2), MMP12(2), PDGFB(2) | [63] |
Shown in the table are a subset of the highly ranked chemicals (p < 0.001) that were predicted to have association with lung cancer gene expression (non-smokers) and had evidence of association with the MeSH term "Lung Neoplasms". Columns have similar definitions as Table 2.