Table 4.
Prediction of environmental chemicals associated with breast cancer samples (GSE6883).
| Chemical Predicted | Hypergeometric P-value | Rank (percentile) | q-value | Relevant genes in set (number of references) | Citations |
|---|---|---|---|---|---|
| Progesterone | 2 × 10-4 | 6 (99) | 0.01 | IL6(3), STC1(3), CEBPD(2) | [64,65] |
| Genistein | 6 × 10-4 | 10 (99) | 0.03 | CEBPD(1), APLP2(1), MLF1(1) | [66-68] |
| Estradiol | 7 × 10-4 | 11 (99) | 0.03 | LPL(4), IL6(3), CEBPD(2) | [69-73] |
| Indomethacin | 3 × 10-3 | 17 (99) | 0.05 | CCDC50(1), BIRC3(1), DNAJB(1) | [74] |
| Diethylstilbestrol | 3 × 10-3 | 18 (99) | 0.05 | IL6(1), MARCKS(1), MXD1(1), MMP7(1) | [75,76] |
| Cyclophosphamide | 4 × 10-4 | 19 (99) | 0.06 | IL6(3), MARCKS(1), PSMA5(1) | [77-79] |
| Bisphenol A | 6 × 10-3 | 21 (99) | 0.08 | CEBPD(1), MLF1(1), DTL(1) | [80] |
Shown in the table are a subset of the highly ranked chemicals (p < 0.01) that were predicted to have association with breast cancer gene expression (non-tumorigenic) and had evidence of association with the MeSH term "Breast Neoplasms". Columns have similar definitions as Table 2.