Table 1.

ACAM2000 efficacy studies in animal models

Animal species	Vaccinations	Vaccination dose	Challenge virus and dose	Challenge route	Outcome	Reference
BALB/C mice	ACAM2000™ ACAM1000 Dryvax®	For all 104,105, 106 or 107 pfu/mL	Vaccinia virus-WR strain 100 × LD50	IN	All vaccines provided equivalent protection	Monath et al6
Cynomolgus macaques	ACAM2000™ Dryvax®	4.4 × 108 pfu/mL 1.5 × l08 pfu/mL	Monkeypox virus/Zaire79 3.8 × l07 pfu/mL	IV	Dryvax® and ACAM2000™ Provided equivalent protection	Marriott et al22