Fig. 1.

Effects of HNTX-VI and HWTX-III on insect DUM neuron sodium currents

All current traces were induced by depolarizing the cell from a holding potential ranging from −80 to −10 mV. The duration of the test pulse was 20 ms. (a) 1 μmol/L of HNTX-VI and 100 nmol/L of HWTX-III changed the sodium currents in insect neurons; (b) The concentration-dependent effect of HNTX-VI and HWTX-III on sodium currents in insect DUM neurons; (c) Dose-dependent inhibition of sodium current inactivation by HNTX-VI (mean±SE) measured from 5–8 separated experimental cells. The points were fit based on Boltzmann Eq. (1). C _HNTX-VI and C _HWTX-III are the concentrations (mol/L) of HNTX-VI and HNTW-III, respectively