Figure 3. Biodistribution of BMM-carried nanozymes in MPTP-intoxicated mice by IVIS.

MPTP-intoxicated Balb/c mice (15 mg/kg) were i.v. injected with A: Alexa Fluor 680-labeled nanozyme loaded to BMM (5×10⁶ cells /mouse); B: Alexa Fluor 680-labeled BMM loaded with non-labeled nanozyme, and C: Alexa Fluor 680-labeled nanozyme administered alone. Representative images from N=4 mice per group (dorsal planes) taken at various time points demonstrate that both components of the formulation, nanozyme (A) and cell carriers (B), were detected in the brain area in MPTP-intoxicated animals. Noteworthy, BMM and nanozyme in cell carriers were remained at later time points compared with nanozyme administered alone (C).