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. 2010 May 28;4(Suppl 1):S2. doi: 10.1186/1752-0509-4-S1-S2

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Copyright ©2010 Wang et al; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functionally related microRNAs tend to be associated with Phenotypically similar diseases. (A) The observed average phenotypic similarity score (arrow) of 349 phenotype pairs associated with common microRNAs and the distribution of expected average phenotypic similarity scores (curve) of 10,000 random control sets containing the same number of randomly sampled phenotype pairs (p<10^-4). (B, C) The observed average functional relatedness (arrow) of 1,252 microRNA pairs associated with common diseases and the distribution of the expected average functional relatedness (curve) of 10,000 random control sets containing the same number of randomly sampled microRNA pairs (p<10^-4). The measures for functional relatedness between microRNAs are the average number of shared network neighbors and a function value that is derived from the shortest path length.