Table 5.
All cause mortality | Breast specific mortality | Person-Years Lost | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
ECRIC Model: |
Hormone coefficient | Chemotherapy coefficient | A | P | ROC | A | P | ROC | Total Possible PY‡ | A | P |
Full | Model | Model | 1,075 | 1,082 | 0.81 | 737 | 768 | 0.84 | 35,003 | 3,099 | 3,341 |
Full | Overview* | Overview | 1,075 | 984 | 0.81 | 737 | 660 | 0.83 | 35,003 | 3,099 | 3,030 |
Constrained | Model† | Model | 1,075 | 980 | 0.81 | 737 | 656 | 0.83 | 35,003 | 3,099 | 3,061 |
Constrained | Overview | Overview | 1,075 | 990 | 0.81 | 737 | 667 | 0.83 | 35,003 | 3,099 | 3,089 |
WMCIU Model: |
|||||||||||
Full | Model | Model | 955 | 1,006 | 0.79 | 668 | 743 | 0.82 | 28,322 | 2,405 | 2,513 |
Full | Overview | Overview | 955 | 956 | 0.79 | 668 | 690 | 0.81 | 28,322 | 2,405 | 2,376 |
Constrained | Model† | Model | 955 | 952 | 0.78 | 668 | 685 | 0.81 | 28,322 | 2,405 | 2,406 |
Constrained | Overview | Overview | 955 | 965 | 0.78 | 668 | 699 | 0.81 | 28,322 | 2,405 | 2,436 |
*Application of overview estimates is performed by setting the model-derived therapy coefficient to zero. Overview-derived therapy risk reductions (first generation) are then applied in the life table analysis. The risk reductions are only applied to individuals who actually received therapy. No Overview hormone therapy benefit was applied to individuals with ER- tumors.
†Under the constrained model, the model coefficient for adjuvant hormone therapy is the same as the Overview estimate.
‡Follow-up was censored at eight years