Table 4.
Comparison of pathologic features of ER-positive BRCA1-associated breast cancers and ER-positive sporadic breast cancers
| Covariates | BRCA1 + | Sporadic | |||
| n | % | N | % | Logistic likelihood ratio test P | |
| All | 47 | 100 | 138 | 100 | |
| Mean age in years (range) | 46 (29-72) | 46 (29-72) | |||
| Histologic type | |||||
| Invasive ductal only | 35 | 74 | 78 | 57 | 0.03 |
| All others | 12 | 26 | 60 | 43 | |
| Mixed ductal/lobular | 10 | 21 | 25 | 18 | |
| Lobular | 1 | 2 | 12 | 9 | |
| Mixed ductal + special type | 0 | 0 | 8* | 6 | |
| Special type | 1+ | 2 | 15++ | 11 | |
| Histologic grade | |||||
| 3 | 18 | 38 | 34 | 25 | 0.10 |
| 2 | 15 | 32 | 69 | 50 | 0.39 |
| 1 | 13 | 28 | 35 | 25 | 0.69 |
| Unknown | 1 | 2 | 0 | 0 | |
| Mitoses/10 HPF | |||||
| >10 | 9 | 19 | 9 | 7 | 0.03 |
| 6-10 | 12 | 26 | 31 | 22 | 0.67 |
| 0-5 | 25 | 53 | 98 | 71 | 0.03 |
| Unknown | 1 | 2 | 0 | 0 | |
| Margins | |||||
| Invasive | 43 | 91 | 134 | 97 | 0.12 |
| Pushing | 3 | 6 | 2 | 1 | 0.09 |
| Unknown | 1 | 2 | 2 | 1 | |
| Lymphocytic infiltrate | |||||
| Moderate/marked | 2 | 4 | 17 | 12 | 0.08 |
| None/mild | 44 | 94 | 121 | 88 | |
| Unknown | 1 | 2 | 0 | 0 | |
| Geographic necrosis/fibrotic focus | |||||
| Yes | 7 | 15 | 9 | 7 | 0.09 |
| No | 38 | 81 | 129 | 93 | |
| Unknown | 2 | 4 | 0 | 0 | |
ER, estrogen receptor; HPF, high powered field.
Percentages calculated by column
* Mixed ductal plus: mucinous (n = 4), invasive micropapillary (n = 2), invasive papillary (n = 1), tubular (n = 1)
+ tubular (n = 1)
++ tubular (n = 6), mucinous (n = 5), invasive micropapillary (n = 2), invasive cribriform (n = 1), mixed invasive
micropapillary/mucinous (n = 1)