Table 1.

Role of the NuRD and Sin3 complex subunits and their respective homologs in development of different model organisms, inferred from genetic (e.g. mutation or deletion) experiments

Gene	Organism	Developmental role	References
Hdac1/2
Hda-1	Caenorhabditis elegans	Embryonic viability, vulval development	Shi and Mello (1998), Solari and Ahringer (2000)
Rpd3	Drosophila melanogaster	Embryonic segregation, groucho-mediated transcriptional repression	Chen et al. (1999), Mannervik and Levine (1999)
Hdac1	Mus musculus	Embryonic viability (die at ~9.5 dpc), control of proliferation	Lagger et al. (2002), Montgomery et al. (2007)
Hdac2	M. musculus	Body size?	Montgomery et al. (2007), Zimmermann et al. (2007)
Rbbp4/7
Lin-54	C. elegans	Embryonic viability, vulval development	Lu and Horvitz (1998), Shi and Mello (1998), Solari and Ahringer (2000)
Rba-1	C. elegans	Embryonic viability, vulval development	Shi and Mello (1998), Solari and Ahringer (2000)
Mi-2
Pickle	Arabidopsis thaliana	Repression of embryonic and meristem genes	Eshed et al. (1999), Ogas et al. (1999)
let-418	C. elegans	Larval viability, vulval development, maintenance of germline-soma distinctions	Solari and Ahringer (2000), Unhavaithaya et al. (2002), von Zelewsky et al. (2000)
dMi-2	D. melanogaster	Hox repression, larval and germ cell viability	Kehle et al. (1998)
Chd4	M. musculus	Haematopoiesis, epidermal development, peri-implantation development	Kashiwagi et al. (2007), Williams et al. (2004), Yoshida et al. (2008), Costello and Hendrich (unpublished)
Mta1/2
Egl-27	C. elegans	Embryonic patterning, Hox regulation, Wnt signalling, vulval development	Ch’ng and Kenyon (1999), Herman et al. (1999), Solari and Ahringer (2000), Solari et al. (1999)
Egr-1	C. elegans	Embryonic patterning, Hox regulation, vulval development	Ch’ng and Kenyon (1999), Solari and Ahringer (2000), Solari et al. (1999)
Mta2	M. musculus	Embryonic development and viability	Lu et al. (2008)
Mbd3
dMbd2/3	D. melanogaster	Stability of peri-centric heterochromatin, suppressor effect on peri-centric position effect variegation	Marhold et al. (2004)
Mbd2/3	C. elegans	Morphological defects (post-embryonic)	Gutierrez and Sommer (2004)
Mbd2	M. musculus	None detected	Hendrich et al. (2001)
Mbd3	M. musculus	Lineage commitment of pluripotent cells, silencing of pre-implanation genes	Kaji et al. (2006), Kaji et al. (2007)
Gatad2a/b
Simj (p66)	D. melanogaster	Embryonic viability, Wnt signalling	Kon et al. (2005)
Gatad2a (p66)	M. musculus	Pleiotrophic effects post-gastrulation, silencing of a few TE genes	Marino and Nusse (2007)
Sin3
Sin3a	M. musculus	Peri-implantation development, cell proliferation	Cowley et al. (2005), Dannenberg et al. (2005)
Sin3a	D. melanogaster	Embryonic viability, Wnt signalling, cell cycle progression	Pennetta and Pauli (1998), Pile et al. (2002), Tsai et al. (1999)
Sin3b	M. musculus	Embryonic viability, terminal differentiation	David et al. (2008)
Suds3 (Sds3)	M. musculus	Centromere function, cell viability	David et al. (2003)
Arid4a (Rbbp1)	M. musculus	Genomic imprinting?	Wu et al. (2006)
Arid4b (Sap180)	M. musculus	Peri-implantation development	Wu et al. (2006)

Alternate names for genes are given in parentheses. Modified and updated from Solari and Ahringer (2000).