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. 2010 Jan 6;30(1):99–109. doi: 10.1523/JNEUROSCI.4305-09.2010

Figure 4.

Figure 4.

Effect of TTA-P2 on rat TC neuron excitability. A, Typical example of the reversible block by TTA-P2 (3-min-long application, 1 μm) of the rebound LTCP evoked at the end of a 1.5-s-long hyperpolarizing step in a rat TC neuron. Ba, The block of the rebound LTCP by 1 μm TTA-P2 was not associated with a change in the depolarizing sag (*) of the hyperpolarizing response to an intracellular current step. Bb, The membrane potential responses observed after repolarization in both conditions are superimposed at a larger time scale. Ca, Superimposed voltage traces illustrate the lack of effect of 1 μm TTA-P2 on membrane potential steps induced by injection of depolarizing currents (control, gray traces; TTA-P2, black traces). Cb, An I–V plot for similar experiments as in a from four TC neurons. Da, Typical example of the tonic firing observed in control condition and after 1 μm TTA-P2 application (same cell as in B). A similar number of action potentials (n = 32) is evoked during a 200 pA step depolarization in both control and TTA-P2 conditions. The first action potential recorded in control and in TTA-P2 conditions are enlarged in Db. Note the lack of effect of TTA-P2 on the threshold (Th), amplitude, half-width, and afterhyperpolarization (AHP) of the action potential. The graph in Dc presents the frequency–current plot from six neurons. CTR, Control.