Figure 4. Selectivity profiling of kinase inhibitors.

a | The number of kinases available for screening from commercial vendors by year. the complete human kinome includes approximately 520 protein kinases⁹⁵ and a smaller number of lipid and small molecule kinases. b | Landmark papers in kinase inhibitor selectivity profiling⁸⁹–⁹¹,⁹³,⁹⁶,⁹⁷, plotted against the number of selectivity measurements (kinases × drugs) that were reported. Representatives from three different approaches that measure inhibitor binding are shown.