Table 1.

US FDA-approved kinase inhibitors

Drug	Key targets for therapeutic activity	US FDA-approved indication
Imatinib	BCR–ABL, PDGFR and KIT	CML and GIST
Dasatinib	BCR–ABL	CML
Nilotinib	BCR–ABL	CML
Gefitinib	EGFR	Lung cancer
Erlotinib	EGFR	Lung and pancreatic cancers
Lapatinib	EGFR and ERBB2	Breast cancer
Sunitinib	VEGFR2, PDGFR and KIT	Kidney cancer and GIST
Sorafenib	VEGFR2 and PDGFR	Kidney and liver cancers
Pazopanib	VEGFR2, PDGFR and KIT	Kidney cancer
Everolimus	mTOR	Kidney cancer
Antibody
Trastuzumab	ERBB2	Breast cancer
Cetuximab	EGFR	Colorectal, and head and neck cancers
Panitumumab	EGFR	Colorectal cancer
Bevacizumab	VEGF	Colorectal, lung and breast cancers

CML, chronic myeloid leukaemia; EGFR, epidermal growth factor receptor; FDA, Food and Drug Administration; GIST, gastrointestinal stromal tumour; PDGFR, platelet-derived growth factor receptor; VEGFR2, vascular endothelial growth factor receptor 2.