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. 2010 Jan 13;30(2):573–582. doi: 10.1523/JNEUROSCI.3295-09.2010

Figure 5.

Figure 5.

Disruption of P2X7 receptor signaling attenuates both LPS- and ATP-induced p-p38 MAPK phosphorylation in mouse dorsal horn slices. A, LPS superfusion results in an increase in p38 MAPK phosphorylation in SC slices from wild-type mice, which is absent in SC slices from P2X7 knock-out mice. Similarly, following LPS priming, ATP superfusion results in an increase in p38 MAPK phosphorylation in SC slices from wild-type mice, which is attenuated in P2X7 receptor knock-out mice. Scale bars, 100 μm. B, Quantification of p-p38 immunoreactivity in mouse SC slices (n = 5–6 slices per group). ***p < 0.001 knock-out versus wild-type, †p < 0.05 compared to indicated group, one-way ANOVA, post hoc Tukey's test.