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. Author manuscript; available in PMC: 2011 May 18.
Published in final edited form as: Dev Cell. 2010 May 18;18(5):687–688. doi: 10.1016/j.devcel.2010.05.001

Figure 1. Dynamin protein domains and the newly solved structures.

Figure 1

(A) Protein domains in Dynamin and MxA. (B) Dynamin GTPase-GED fusion protein crystallized by Chappie et al. (2010). Amino and carboxy terminal α-helices are indicated by N1, C1 and C2. (C) MxA fragment crystallized by Gao et al. (2010). (D) Key features of the GTPase-GED structure, showing dimerization of two GTPase domains. The interface with GTP-binding sites (1) is buried in this drawing. The BSE is formed by interactions between N1, C1 and C2 helices (2). (E) Key features of the MD-GED structure, showing interactions with adjacent subunits at three different points (3–5) (F) Hypothetical arrangement of dynamin subunits in a spiral suggested by the newly identified interactions and by cryoEM.