Figure 2.

(A) Steady state baseline fluorescence emission, reflective of PLact within each of the target tissue compartments was equivalent in pigs randomized to either vehicle (saline) or TXA (30mg/kg). Thus, the baseline fluorescence emissions between the two groups was comparable prior to initiation of treatment (plotted values are mean±SEM, *p < 0.05).

(B) Representative fluorescence emission measurements within the liver tissue compartment were obtained at baseline (time 0) and 30, 60, 90 and 120 minutes following either vehicle (saline) or TXA (30mg/kg) infusion. There was a notable increase in absolute fluorescence emission over time following vehicle (saline) infusion. In contrast, there was an overall decrease in fluorescence emission over time, reflective of reduced PLact within the liver following TXA administration. The summary data reflective of PLact across each target compartment and all time intervals are shown in figure 3.