Table 3.
Proteins identified from mitochondria of PS1 transgenic mice showing no significant relative abundance change vs control littermates at the same age from young (3, 6 months) to old (12 months) ages.
| No. | Protein access number and description | Age (Month) | ANOVA-test (p<0.05) | ||||
|---|---|---|---|---|---|---|---|
| 3 | 6 | 12 | 3 – 6 | 3 – 12 | 6 – 12 | ||
| 1 |
Q99LC3|NDUAA_MOUSE NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor (EC 1.6.5.3) (Complex I- 42kD) |
0.99 (0.05) |
1.05 (0.06) |
1.17 (0.20) |
no | no | no |
| 2 |
P99028|UCRH_MOUSE Ubiquinol-cytochrome c reductase complex 11 kDa protein, mitochondrial precursor (EC 1.10.2.2) (Complex III subunit VIII) |
0.88 (0.05) |
1.08 (0.08) |
1.54 (0.43) |
yes | no | no |
| 3 |
Q64521|GPDM_MOUSE Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) |
1.04 (0.04) |
1.05 (0.10) |
1.17 (0.13) |
no | no | no |
| 4 |
P99029|PRDX5_MOUSE Peroxiredoxin-5, mitochondrial precursor (EC 1.11.1.15) (Prx-V) |
0.89 (0.07) |
1.07 (0.11) |
1.12 (0.12) |
no | no | no |
| 5 |
Q9D0K2|SCOT_MOUSE Succinyl-CoA:3 ketoacid-coenzyme A transferase 1, mitochondrial precursor (EC 2.8.3.5) |
0.81 (0.01) |
1.09 (0.13) |
1.26 (0.07) |
yes | yes | no |
| 6 |
P68369|TBA1_MOUSE Tubulin alpha-1 chain (Alpha-tubulin 1) |
1.42 (0.09) |
1.12 (0.09) |
0.94 (0.02) |
no | yes | no |
| 7 |
P68368|TBA4_MOUSE Tubulin alpha-4 chain (Alpha-tubulin 4) |
1.22 (0.09) |
1.06 (0.04) |
1.12 (0.15) |
yes | no | no |
| 8 | Q7TMM9|TBB2A_MOUSE Tubulin beta-2A chain | 1.05 (0.43) |
1.06 (0.14) |
0.66 (0.14) |
no | no | yes |
| 9 |
P26443|DHE3_MOUSE Glutamate dehydro- genase 1, mitochondrial precursor (EC 1.4.1.3) (GDH) |
1.02 (0.10) |
1.20 (0.09) |
1.38 (0.09) |
no | yes | no |
| 10 |
P11798|KCC2A_MOUSE Calcium/calmodulin- dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) |
1.12 (0.08) |
1.25 (0.03) |
0.95 (0.21) |
no | no | no |
| 11 |
Q9CR21|ACPM_MOUSE Acyl carrier protein, mitochondrial precursor (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (CI-SDAP) |
1.09 (0.13) |
0.99 (0.05) |
1.36 (0.07) |
no | no | yes |
| 12 |
Q9QYG0|NDRG2_MOUSE Protein NDRG2 (Protein Ndr2) |
0.90 (0.10) |
1.04 (0.03) |
0.75 (0.07) |
no | no | yes |
| 13 |
O08599|STXB1_MOUSE Syntaxin-binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) |
1.41 (0.05) |
1.18 (0.05) |
1.54 (0.89) |
yes | no | no |
| 14 |
P62814|VATB2_MOUSE Vacuolar ATP synthase subunit B, brain isoform (EC 3.6.3.14) |
1.27 (0.24) |
1.24 (0.40) |
0.59 (0.02) |
no | yes | no |
| 15 |
P60202|MYPR_MOUSE Myelin proteolipid protein (PLP) (Lipophilin) |
1.74 (0.23) |
1.44 (0.12) |
1.05 (0.11) |
no | yes | No |
| 16 |
Q8VEM8|MPCP_MOUSE Phosphate carrier protein, mitochondrial precursor (PTP) (Solute carrier family 25 member 3) |
1.30 (0.22) |
1.09 (0.09) |
1.70 (0.14) |
no | no | yes |
| 17 |
Q8BFR5|EFTU_MOUSE Elongation factor Tu, mitochondrial precursor |
1.00 (0.11) |
1.11 (0.13) |
2.06 (0.42) |
no | no | no |
| 18 |
Q60931|VDAC3_MOUSE Voltage-dependent anion-selective channel protein 3 (VDAC-3) (mVDAC3) (Outer mitochondrial membrane protein porin 3) |
1.92 (0.24) |
1.27 (0.28) |
2.19 (0.57) |
no | no | no |
| 19 |
O08749|DLDH_MOUSE Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) |
1.09 (0.09) |
1.10 (0.06) |
1.77 (0.27) |
no | no | no |
| 20 |
Q9D0M3|CY1_MOUSE Cytochrome c1, heme protein, mitochondrial precursor (Cytochrome c-1) |
0.99 (0.01) |
1.15 (0.03) |
1.69 (0.27) |
yes | no | no |
| 21 |
Q9CR61|NDUB7_MOUSE NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (EC 1.6.5.3) (Complex I-B18) |
1.01 (0.06) |
1.31 (0.05) |
2.03 (0.56) |
yes | no | no |
| 22 |
Q9D6M3|GHC1_MOUSE Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) |
1.00 (0.13) |
1.19 (0.23) |
2.11 (0.46) |
no | yes | no |
| 23 |
Q791V5|MTCH2_MOUSE Mitochondrial carrier homolog 2 |
1.07 (0.02) |
0.90 (0.04) |
1.39 (0.20) |
yes | no | yes |
| 24 |
P63038|CH60_MOUSE 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Mitochondrial matrix protein P1) (HSP-65) |
0.94 (0.03) |
1.15 (0.16) |
1.87 (0.35) |
no | yes | no |
| 25 |
Q9D172|ES1_MOUSE ES1 protein homolog, mitochondrial precursor |
0.86 (0.11) |
0.93 (0.01) |
0.86 (0.11) |
no | no | no |