Table 1. Relationship between adipose tissue gene expression and BMI for the putative causative genes among 77 unrelated subjects (Pearsonian correlation and associated P-value), fold change, and P-value for the intrapair difference in gene expression between obese and lean members of obesity discordant MZ pairs.
| Unrelated subjects | Discordant MZ twin pairs | ||||
| Gene symbol | Affymetrix probe-ID | Pearson Correlation | P-valuea | Obese/Lean Expressionb | P-valuec |
| SAP30BP | 217965_s_at | −0.51 | 9.99×10−5 | 1.00 | 0.56 |
| MRPL9 | 209609_s_at | −0.43 | 9.57×10−5 | 0.89 | 0.72 |
| C20orf198 | 226149_at | −0.35 | 9.26×10−5 | 0.93 | 0.45 |
| IVNS1ABP | 206245_s_at | 0.46 | 8.86×10−5 | 1.24 | 0.08 |
| SPSB3 | 46256_at | −0.52 | 8.32×10−5 | 0.93 | 0.06 |
| SART1 | 200051_at | −0.34 | 8.29×10−5 | 1.01 | 0.83 |
| ST3GAL6 | 210942_s_at | −0.52 | 8.27×10−5 | 0.77 | 0.05 |
| FAHD2A | 222056_s_at | −0.41 | 8.05×10−5 | 0.97 | 0.53 |
| mRNA AK125162 | 231040_at | −0.42 | 7.95×10−5 | 0.83 | 0.85 |
| SH3BGR | 204979_s_at | 0.32 | 5.0×10−5 | 1.13 | 0.11 |
| NPY1R | 205440_s_at | 0.42 | 5.0×10−5 | 1.15 | 0.14 |
| EIF2B4 | 209429_x_at | −0.48 | 4.83×10−5 | 1.07 | 0.62 |
| EIF4EBP1 | 221539_at | −0.54 | 4.55×10−5 | 0.82 | 0.08 |
| AATF | 209165_at | −0.46 | 4.26×10−5 | 1.03 | 0.44 |
| PRDX6 | 200844_s_at | −0.48 | 3.39×10−5 | 0.93 | 0.18 |
| SH3BGRL | 201312_s_at | 0.38 | 3.33×10−5 | 1.12 | 0.18 |
| PCBD1 | 203557_s_at | −0.56 | 3.1×10−5 | 0.88 | 0.05 |
| PRSS23 | 226279_at | 0.33 | 2.78×10−5 | 1.11 | 0.07 |
| BC007882 | 225657_at | −0.28 | 2.72×10−5 | 0.96 | 0.67 |
| ST3GAL6 | 213355_at | −0.47 | 2.48×10−5 | 0.97 | 0.24 |
| TMEM101 | 225004_at | −0.36 | 1.79×10−5 | 0.96 | 0.11 |
| F13A1 | 203305_at | 0.41 | 9.59×10−6 | 1.13 | 0.11 |
| TRAP1 | 201391_at | −0.38 | 6.53×10−6 | 0.98 | 0.43 |
| CRY2 | 212695_at | −0.41 | 5.35×10−6 | 0.92 | 0.22 |
| PPIE | 210502_s_at | −0.6 | 4.9×10−6 | 0.97 | 0.54 |
| C16orf62 | 225772_s_at | −0.43 | 4.9×10−6 | 0.83 | 0.06 |
| RNASE4 | 213397_x_at | −0.44 | 2.68×10−6 | 0.86 | 0.09 |
| HADHA | 208630_at | −0.5 | 2.5×10−6 | 1.03 | 0.35 |
Table has been sorted according to the P-value of the Pearson correlation.
a
P-value for the Pearson correlation between BMI and gene expression in the set of 77 unrelated individuals.
b
Median fold difference in gene expression between the obese and lean co-twins. Values greater than 1.00 represent a higher expression level in the obese twin.
c
P-value for non-parametric Welch t-test of gene expression between lean and obese co-twins of obesity discordant pairs.