Table 4. 10 top most overrepresented (Ov) new families, from the set of over 180 curated novel families identified in this work.

Family ID	Family description	g	n	G	N	Ov/Ex/Es	Most advanced PSI target (id, center, status)
PB004588	No hypothesis about function	105	0	14	0	666.89/7.00/0.22	390317, JCSG, Diffraction-quality Crystals
PB064361	Contains putative lipoproteins	60	0	13	0	381.08/4.29/0.20	#N/A
PB012771	No hypothesis about function	92	1	21	1	292.16/3.68/0.32	NYSGXRC-T1444, NYSGXRC, Work Stopped
PB008694	Contains conserved hypothetical proteins found in conjugate transposon TraH.	40	0	13	0	254.05/2.86/0.20	390153, JCSG, Diffraction-quality crystals
HGC00311	No hypothesis about function	35	0	16	0	222.30/2.06/0.25	#N/A
PB023339	No hypothesis about function	32	0	13	0	203.24/2.29/0.20	NYSGXRC-12097b, NYSGXRC, Native diffraction data
HGC00150	No hypothesis about function	31	0	15	0	196.89/1.94/0.23	#N/A
PB029229	No hypothesis about function	28	0	13	0	177.84/2.00/0.20	393207, JCSG, Crystallized
PB048420	No hypothesis about function	27	0	18	0	171.49/1.42/0.28	#N/A
PB047024	Remote homology to HD domain (PF01966)	24	0	22	0	152.43/1.04/0.34	#N/A

Exact definitions of the Ov category is given in the Methods section. Columns provide numerical values for: g (total number of representatives in genomes of human gut microbiome microbes), n (total number of representatives in genomes of microbes not associated with human gut microbiome), G (number of microbes from human gut microbiome with at least representative of a family) and N (number of microbes not associated with human gut microbiome with at least representative of a family).