Table 5. 10 top most expanded (Ex) new families, from the set of over 180 curated novel families identified in this work.

Family ID	Family description	g	n	G	N	Ov/Ex/Es	Most advanced PSI target (id, center, status)
PB155142	Contains putative TonB-linked outer membrane proteins, part of SusC? Remote homology to several outer membrane receptors	930	158	14	58	37.15/59.32/0.10	#N/A
HGC00106	Contains putative TonB-linked outer membrane proteins, part of SusC?	908	76	14	8	74.90/52.09/0.20	APC62223.1, MCSG, Purified
HGC00024	N-terminal subdomain of SusD	819	56	14	6	91.26/46.60/0.20	3ejn, JCSG, In PDB
PB001404	Branch of SusD family	764	61	13	5	78.27/44.40/0.19	3cgh, JCSG, In PDB
PB004588	No hypothesis about function	105	0	14	0	666.89/7.00/0.22	390317, JCSG, Diffraction-quality Crystals
PB064361	Contains putative lipoproteins	60	0	13	0	381.08/4.29/0.20	#N/A
PB012771	No hypothesis about function	92	1	21	1	292.16/3.68/0.32	NYSGXRC-T1444, NYSGXRC, Work Stopped
PB000790	Branch of SusD family	98	17	13	4	34.58/3.60/0.19	3cgh, JCSG, In PDB
PB202086	Remote homology to Flagellar basal body-associated protein	21	0	5	0	133.38/3.50/0.08	#N/A

Exact definitions of the Ex category is given in the Methods section. For the details of the Table 5 columns see the legend for Table 4.