Figure 1. Effect of β-catenin stabilization on Wnt target gene expression.

β -galactosidase staining on whole mount (a,a') and coronal section (b,b') and whole mount in situ hybridization (c–g') of E8.5 (c–c') and E9.5 (d–g') wt (a–g) and β-catenin^lof (a'–g') embryos. Probes were against Drapc1, Axin2, Tcf1, Dkk1. Arrows indicate changes in gene expression. Arrowheads point to down-regulation of Axin2 and Tcf1 in ventral midbrain.