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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Neuroimage. 2010 Mar 17;51(4):1294–1302. doi: 10.1016/j.neuroimage.2010.03.016

Table 3.

Regions where brain activity correlated with white matter hyperintensities (WMH):

A. correlations with global WMH burden (n=25, threshold P<0.01 uncorrected); B. correlations with WMH burden in superior longitudinal fasciculus (SLF) (n=10, threshold P < 0.01 uncorrected). Coordinates are given in MNI space.

Region Coordinates Z-Value Voxel Level Significance (uncorrected)
x y z
A. Global WMH burden
Positive Correlations:
Cluster 1: Cerebellum and Brainstem; P<0.000 (corrected)
Cerebellum, Anterior Lobe −6,12 −50, −46 −24, −26 4.86,4.84*
Cerebellum, Anterior Lobe −24 −44 −26 3.25
Cerebellum, Posterior Lobe 24,38 −40, −60 −32, −30 4.27,4.25
Cerebellum, Posterior Lobe 10 −60 −38 4.02
Pons (PMC) 8,0 −28, −30 −30, −32 3.58,3.48
Left Pons −16 −34 −28 3.70
Midbrain (PAG) −2 −28 −18 2.44
Cluster 2: SMA, Superior/Medial Frontal Gyrus adjacent to Dorsal ACG; P<0.000 (corrected)
Postcentral Gyrus (BA3) −56, −24 −14, −32 22,64 4.08,3.60
Precentral Gyrus (BA 4) −16, −32 −20, −16 60,54 3.96,3.20
Precentral Gyrus (BA 6) −48 −6 22 3.19
Precentral Gyrus 48,54 2,0 46,26 3.84,3.30
Medial Frontal Gyrus (BA 6) 14, −10 −20, −14 54,48 3.68,3.64
Medial Frontal Gyrus (BA 32) 12 14 44 3.48
Superior Frontal Gyrus (BA 6) 8,8 2,24 66,58 3.53,3.09
Anterior Cingulate Gyrus (BA24) −20 −12 44 3.77
Inferior Frontal Gyrus (BA 9) −54 4 28 3.37
Left Insula (BA13) −38 −8 6 3.12
Paracentral Lobule (BA31) 0 −22 42 3.59
Superior Temporal Gyrus (BA 22) −50 −2 6 3.57
Other Regions:
Middle frontal gyrus (BA 8) 30 20 42 2.83 0.002
Thalamus (ventral posterior lateral nucleus) 18 −20 6 2.99 0.001
Midbrain, Red nucleus 8 −18 −4 2.84 0.002
Hippocampus/parahipocampus 28 −20 −14 3.12 0.001
Cuneus (BA18) −2 −94 10 3.15 0.001
Negative Correlations:
Anterior Cingulate Gyrus (BA 24) 4 24 −4 2.93 0.002
Caudate 12 26 −4 2.72 0.002
Precuneus (BA 7) 4 −62 32 2.66 0.004
B. Superior Longitudinal Fasciculus (Entire Pathway)
Negative Correlations:
Cluster 1: Dorsal ACG/Medial Frontal Gyrus; P < 0.006 (uncorrected)
Anterior Cingulate Gyrus (BA24/32) 6, −4 22,24 24,36 3.53,3.44
Medial Frontal Gyrus (BA 9/8) 10,4 38,26 28,38 3.15,3.06
ACG/BA 32 −2,2 20,20 28,28 3.12,3.12
Other Regions:
Left Parietal Lobe (Angular Gyrus/BA 39) −42 −58 36 4.21 0.000
Inferior Frontal Gyrus/BA13 40 20 8 2.80 0.003
*

Significant after corrections for multiple comparisons (FWE, P < 0.05)