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. Author manuscript; available in PMC: 2010 Jun 3.
Published in final edited form as: J Am Chem Soc. 2009 Mar 4;131(8):2821–2823. doi: 10.1021/ja8094558

Figure 1.

Figure 1

Model demonstrating second site screening for the hydrophobic pocket. A spin label or EDTA moiety is attached to an outer C-peptide (green) which binds in a site adjacent to the pocket. The coiled coil is shown as an orange surface with the floor of the pocket emphasized in yellow. The small ligand p-fluorobenzylbenzoic acid is shown docked in a pose which agrees with the NMR data (see text).